Combining PRP and Microneedling to Facilitate Hair Regrowth
Hair loss is a prevalent concern affecting millions in the United States, with androgenetic alopecia (AGA) being one of the most common forms, affecting approximately 50 million men and 30 million women across the country as of 2023. AGA often leads to significant psychological distress and impact on self-esteem.
Traditional treatments, such as minoxidil and finasteride, have shown varying degrees of efficacy but often fail to deliver satisfactory results for all patients. As a result, innovative approaches have emerged, including the combination of Platelet-Rich Plasma (PRP) therapy and microneedling.
This article examines the synergistic effects of combining PRP therapy and microneedling in treating hair loss, primarily focusing on AGA.
Traditional treatments, such as minoxidil and finasteride, have shown varying degrees of efficacy but often fail to deliver satisfactory results for all patients. As a result, innovative approaches have emerged, including the combination of Platelet-Rich Plasma (PRP) therapy and microneedling.
This article examines the synergistic effects of combining PRP therapy and microneedling in treating hair loss, primarily focusing on AGA.
Efficacy of Microneedling and PRP as Standalone Treatments

As standalone treatments, both microneedling and PRP are popular methods to treat hair loss, especially for people with Androgenetic Alopecia (AGA). Microneedling utilizes thin needles to generate micro-injuries on the scalp.
This process stimulates the body’s natural healing cascade, promoting collagen production and enhancing blood circulation to hair follicles. Studies have shown that microneedling can significantly improve hair density and thickness, with many patients reporting positive outcomes.
PRP therapy involves drawing a small amount of the patient’s blood, processing it to concentrate the platelets, and injecting this enriched plasma into the scalp. The growth factors contained in PRP are believed to stimulate hair follicle regeneration and improve overall scalp health. Research indicates that PRP can enhance hair density and promote hair growth when injected directly into areas affected by hair loss.
This process stimulates the body’s natural healing cascade, promoting collagen production and enhancing blood circulation to hair follicles. Studies have shown that microneedling can significantly improve hair density and thickness, with many patients reporting positive outcomes.
PRP therapy involves drawing a small amount of the patient’s blood, processing it to concentrate the platelets, and injecting this enriched plasma into the scalp. The growth factors contained in PRP are believed to stimulate hair follicle regeneration and improve overall scalp health. Research indicates that PRP can enhance hair density and promote hair growth when injected directly into areas affected by hair loss.
Can Microneedling and PRP Be Combined for Hair Regrowth?
Combining microneedling with PRP therapy offers several advantages that can enhance treatment outcomes for patients experiencing hair loss. One of the primary benefits is the synergistic effect of both treatments.
The microchannels created by microneedling facilitate better absorption of topical treatments and optimize the delivery of PRP when injected immediately after microneedling. This dual approach effectively leverages the strengths of each method—micro-needling’s ability to induce healing and PRP’s regenerative properties—potentially leading to superior clinical outcomes.
Moreover, combining these therapies may reduce treatment time and increase patient satisfaction. The combination also addresses multiple aspects of hair restoration, including improved scalp health, enhanced blood flow, and increased collagen production, all of which contribute to a more favorable environment for hair growth.
The microchannels created by microneedling facilitate better absorption of topical treatments and optimize the delivery of PRP when injected immediately after microneedling. This dual approach effectively leverages the strengths of each method—micro-needling’s ability to induce healing and PRP’s regenerative properties—potentially leading to superior clinical outcomes.
Moreover, combining these therapies may reduce treatment time and increase patient satisfaction. The combination also addresses multiple aspects of hair restoration, including improved scalp health, enhanced blood flow, and increased collagen production, all of which contribute to a more favorable environment for hair growth.
Clinical Evidence Supporting Combination Therapy
Several studies have demonstrated the efficacy of combining PRP with microneedling. For instance, a study involving patients with AGA showed significant improvements in hair density after undergoing multiple microneedling sessions, followed by PRP injections. Patients reported higher satisfaction levels compared to those receiving either treatment alone.
Further supporting the effectiveness of this combined approach, a meta-analysis conducted by Kang and Lu (2022) reviewed multiple controlled studies and found that patients receiving microneedling in conjunction with PRP experienced a greater than 50% improvement in clinical outcomes compared to those treated with microneedling alone.
The analysis included data from 472 patients across various studies, revealing an odds ratio of 2.97 for significant clinical improvement when both treatments were utilized together. Additionally, the study highlighted that combination therapy improved patient satisfaction rates and maintained a favorable safety profile, with no significant increase in adverse events compared to microneedling alone. Such compelling evidence reinforces that integrating PRP with microneedling can significantly enhance treatment outcomes for hair loss and other dermatological conditions.
Further supporting the effectiveness of this combined approach, a meta-analysis conducted by Kang and Lu (2022) reviewed multiple controlled studies and found that patients receiving microneedling in conjunction with PRP experienced a greater than 50% improvement in clinical outcomes compared to those treated with microneedling alone.
The analysis included data from 472 patients across various studies, revealing an odds ratio of 2.97 for significant clinical improvement when both treatments were utilized together. Additionally, the study highlighted that combination therapy improved patient satisfaction rates and maintained a favorable safety profile, with no significant increase in adverse events compared to microneedling alone. Such compelling evidence reinforces that integrating PRP with microneedling can significantly enhance treatment outcomes for hair loss and other dermatological conditions.
Recommended Protocols for Treatment

Typically, a combined treatment protocol may involve:
- ● Initial Consultation: Assessing patient history and suitability for treatment.
- ● PRP Application: Injecting PRP every 2 to 3 cm throughout the scalp creates tiny blebs covering the treatment area, followed by microneedling to enhance absorption.
- ● Topical PRP and Microneedling Procedure: Apply a topical layer of PRP and microneedle it into the scalp using a device like the FDA-cleared NanoPen® Pro™.
- ● Follow-up Sessions: Repeating the procedure every 4-6 weeks over several months to achieve optimal results.
Most studies suggest that at least four sessions are necessary to observe significant improvements in hair growth.
Safety Profile
PRP therapy and microneedling are generally considered safe procedures with minimal side effects when performed by qualified professionals. Commonly reported side effects include mild pain during treatment, swelling, redness at injection sites, and temporary bruising.
Contraindications
Individuals with the following conditions must be advised against undergoing microneedling and PRP, and alternative options must be provided. Patients with these conditions may present with unwanted outcomes or serious adverse effects after the treatment:
- ● Low platelet count or clotting disorders
- ● Existing infections or dermatological conditions affecting the scalp
- ● Certain cancers or systemic diseases
- ● Use of anticoagulants or certain medications within specified time frames
Patient Selection and Considerations
Effective patient selection is crucial for optimizing outcomes with combined PRP and microneedling therapies. Ideal candidates typically include those with early-stage AGA who have not responded adequately to conventional treatments. A thorough evaluation should include:
- ● Medical history assessment
- ● Physical examination of scalp condition
- ● Discussion of patient expectations and potential outcomes
Educating patients about realistic expectations is essential for satisfaction post-treatment.
Level Up Your Practice with RegenOMedix™ Solutions
The combination of Platelet-Rich Plasma (PRP) therapy and microneedling offers a powerful approach to treating hair loss, particularly androgenetic alopecia. Combining the regenerative properties of PRP with the skin-stimulating effects of microneedling allows healthcare providers to enhance hair density and improve patient satisfaction through a tailored, minimally invasive approach to hair loss treatment.
Integrate the NanoPen® Pro™ by RegenOMedix™ into your treatment protocols to enhance your practice. This FDA-cleared microneedling device is designed for precision and safety, making it an invaluable tool for practitioners seeking to deliver superior results. With adjustable needle depths and an ergonomic design, the NanoPen® Pro™ allows for treatments catering to various skin types and conditions, ensuring optimal patient outcomes.
Contact us today to learn more about how our innovative solutions can transform your practice and improve patient care.
Integrate the NanoPen® Pro™ by RegenOMedix™ into your treatment protocols to enhance your practice. This FDA-cleared microneedling device is designed for precision and safety, making it an invaluable tool for practitioners seeking to deliver superior results. With adjustable needle depths and an ergonomic design, the NanoPen® Pro™ allows for treatments catering to various skin types and conditions, ensuring optimal patient outcomes.
Contact us today to learn more about how our innovative solutions can transform your practice and improve patient care.
This treatment can effectively reduce acne scars and enhance skin texture while addressing active breakouts by regulating oil production. It is essential to avoid microneedling during active acne outbreaks to prevent further irritation; instead, focus on managing breakouts before considering the procedure.
References
Aggarwal, I., Puyana, C., Chandan, N., & Haber, R. (2022). Racial and ethnic disparities in androgenetic alopecia clinical trials in the United States. Journal of Dermatology and Skin Science, 4(4), 15–16.
https://doi.org/10.29245/2767-5092/2022/4.1164
Gentile, P., Garcovich, S., Bielli, A., Scioli, M. G., Orlandi, A., & Cervelli, V. (2015). The effect of Platelet-Rich plasma in hair regrowth: a Randomized Placebo-Controlled trial. Stem Cells Translational Medicine, 4(11), 1317–1323. https://doi.org/10.5966/sctm.2015-0107
Kakizaki, P., Contin, L. A., Barletta, M., Machado, C. J., Michalany, N. S., Valente, N. Y. S., & Donati, A. (2022). Efficacy and safety of scalp microneedling in male pattern hair loss. Skin Appendage Disorders, 9(1), 18–26. https://doi.org/10.1159/000526215
Kang, C., & Lu, D. (2022). Combined Effect of microneedling and Platelet-Rich plasma for the treatment of acne scars: A Meta-Analysis. Frontiers in Medicine, 8. https://doi.org/10.3389/fmed.2021.788754
Yepuri, V., & Venkataram, M. (2021). Platelet-Rich Plasma with Microneedling in Androgenetic Alopecia: Study of Efficacy of the Treatment and the Number of Sessions Required. PubMed, 14(2), 184–190. https://doi.org/10.4103/jcas.jcas_33_20
Gentile, P., Garcovich, S., Bielli, A., Scioli, M. G., Orlandi, A., & Cervelli, V. (2015). The effect of Platelet-Rich plasma in hair regrowth: a Randomized Placebo-Controlled trial. Stem Cells Translational Medicine, 4(11), 1317–1323. https://doi.org/10.5966/sctm.2015-0107
Kakizaki, P., Contin, L. A., Barletta, M., Machado, C. J., Michalany, N. S., Valente, N. Y. S., & Donati, A. (2022). Efficacy and safety of scalp microneedling in male pattern hair loss. Skin Appendage Disorders, 9(1), 18–26. https://doi.org/10.1159/000526215
Kang, C., & Lu, D. (2022). Combined Effect of microneedling and Platelet-Rich plasma for the treatment of acne scars: A Meta-Analysis. Frontiers in Medicine, 8. https://doi.org/10.3389/fmed.2021.788754
Yepuri, V., & Venkataram, M. (2021). Platelet-Rich Plasma with Microneedling in Androgenetic Alopecia: Study of Efficacy of the Treatment and the Number of Sessions Required. PubMed, 14(2), 184–190. https://doi.org/10.4103/jcas.jcas_33_20

Bruce Bertman, CEO of Zizion Group LLC & Networld Online, Inc.
Bruce Bertman, CEO of Zizion Group LLC and Networld Online, Inc., is a distinguished marketing professional with a career spanning work with AT&T, IBM, Inacomp Computer Centers, and numerous charitable organizations. Based in Boca Raton, Florida, he leads Zizion’s global medical device distribution operations and represents the company at international events. As a business innovator and speaker, Bertman launched three companies and guided hundreds of clients to sales success. As CEO of Networld Online, he’s a respected digital marketing leader and visionary who empowers clients and partners to succeed.